Publications – CHAOS Lab

Flavio H. Fenton on Google Scholar

2021

Robust data assimilation with noise: Applications to cardiac dynamics
CD Marcotte, FH Fenton, MJ Hoffman, EM Cherry Chaos: An Interdisciplinary Journal of Nonlinear Science 31 (1), 013118

2020

Experimental validation of a variational data assimilation procedure for estimating space-dependent cardiac conductivities
A Barone, A Gizzi, F Fenton, S Filippi, A Veneziani Computer Methods in Applied Mechanics and Engineering 358, 112615
Generation of Monophasic Action Potentials and Intermediate Forms
S Iravanian, I Uzelac, C Herndon, JJ Langberg, FH Fenton Biophysical Journal 119 (2), 460-469
High-resolution optical measurement of cardiac restitution, contraction, and fibrillation dynamics in beating vs. blebbistatin-uncoupled isolated rabbit hearts
V Kappadan, S Telele, I Uzelac, F Fenton, U Parlitz, S Luther, J Christoph Frontiers in Physiology 11, 464
Accelerating simulations of cardiac electrical dynamics through a multi‐GPU platform and an optimized data structure
EC Vasconcellos, EWG Clua, FH Fenton, M Zamith Concurrency and Computation: Practice and Experience 32 (5), e5528
Excitable dynamics in neural and cardiac systems
R Barrio, S Coombes, M Desroches, F Fenton, S Luther, E Pueyo Communications in Nonlinear Science and Numerical Simulation 86, 105275
Key aspects for effective mathematical modelling of fractional-diffusion in cardiac electrophysiology: A quantitative study
N Cusimano, A Gizzi, FH Fenton, S Filippi, L Gerardo-Giorda Communications in Nonlinear Science and Numerical Simulation 84, 105152
Fatal arrhythmias: Another reason why doctors remain cautious about chloroquine/hydroxychloroquine for treating COVID-19
I Uzelac, S Iravanian, H Ashikaga, NK Bhatia, C Herndon, A Kaboudian, JC Gumbart, EM Cherry, FH Fenton Heart rhythm 17 (9), 1445-1451
Creation and application of virtual patient cohorts of heart models
SA Niederer, Y Aboelkassem, CD Cantwell, C Corrado, S Coveney, EM Cherry, T Delhaas, FH Fenton, AV Panfilov, P Pathmanathan, G Plank, M Riabiz, CH Roney, RW Dos Santos, L Wang Philosophical Transactions of the Royal Society A 378 (2173), 20190558
Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics
SP Pathmanathan, SK Galappaththige, JM Cordeiro, A Kaboudian, FH Fenton, Richard A Gray Frontiers in physiology 11, 1463
Robust data assimilation with noise: Applications to cardiac dynamics
CD Marcotte, FH Fenton, MJ Hoffman, EM Cherry Chaos: An Interdisciplinary Journal of Nonlinear Science 31 (1), 013118

2019

Patterns and Humans
N Manz, FH Fenton Spirals and Vortices, 217-224
Theoretical modeling and experimental detection of the extracellular phasic impedance modulation in rabbit hearts
S Iravanian, C Herndon, JJ Langberg, FH Fenton Frontiers in physiology 10, 883
A Comprehensive Comparison of GPU Implementations of Cardiac Electrophysiology Models
A Kaboudian, HA Velasco-Perez, S Iravanian, Y Shiferaw, EM Cherry, FH Fenton From Reactive Systems to Cyber-Physical Systems, 9-34
Real-time interactive simulations of large-scale systems on personal computers and cell phones: Toward patient-specific heart modeling and other applications
A Kaboudian, EM Cherry, FH Fentonn Science advances 5 (3), eaav6019
Large-scale interactive numerical experiments of chaos, solitons and fractals in real time via GPU in a web browser
A Kaboudian, EM Cherry, FH Fenton Chaos, Solitons & Fractals 121, 6-29
Probabilistic reachability for multi-parameter bifurcation analysis of cardiac alternans
MA Islam, R Cleaveland, FH Fenton, R Grosu, PL Jones, SA Smolka Theoretical Computer Science 765, 158-169
Simulating normal and arrhythmic dynamics: From sub-cellular to tissue and organ level
H Dierckx, FH Fenton, S Filippi, A Pumir, S Sridhar Frontiers in Physics 7, 89:
Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue
A Loppini, A Gizzi, C Cherubini, EM Cherry, FH Fenton, S Filippi Physical Review E 100 (2), 020201
Isosbestic Point in Optical Mapping; Theoretical and Experimental Determination With Di-4-ANBDQPQ Transmembrane Voltage Sensitive Dye
I Uzelac, CJ Crowley, FH Fenton 2019 Computing in Cardiology (CinC), 1-4
Baseline Wandering Removal in Optical Mapping Measurements With PID Control in Phase Space
S Eisner, FH Fenton, I Uzelac 2019 Computing in Cardiology (CinC), 1-4
Parallel Acceleration on Removal of Optical Mapping Baseline Wandering
I Uzelac, S Iravanian, FH Fenton 2019 Computing in Cardiology (CinC), 1-4
Visualizing dynamical systems with fire fronts
N Manz, F Fenton Bulletin of the American Physical Society 64
Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source–Sink Mismatch
SI Grijalva, J Gu, J Li, N Fernandez, J Fan, JH Sung, SY Lee, C Herndon, EM Buckley, SJ Park, FH Fenton, HC Cho Advanced Science 6 (22), 1901099
Simulating waves, chaos and synchronization with a microcontroller
AJ Welsh, C Delgado, C Lee-Trimble, A Kaboudian, FH Fenton Chaos: An Interdisciplinary Journal of Nonlinear Science 29 (12), 123104

2018

Electromechanical vortex filaments during cardiac fibrillation
Christoph J, Chebbok M, Richter C, Schroder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuss G, Gilmour RF, Luther S. Nature, 555(7698)
Probabilistic reachability for multi-parameter bifurcation analysis of cardiac alternans
Islam MA, Cleaveland R, Fenton FH, Grosu R, Jones PL, Smolka SA. Theoretical Computer Science, in press
Spatiotemporal correlation uncovers fractional scaling in cardiac tissue
A Loppini, A Gizzi, C Cherubini, EM Cherry, FH Fenton, S Filippi arXiv preprint arXiv: 1806.04507
Discordant alternans as a mechanism for initiation of ventricular fibrillation In vitro
Laura M Muñoz, Anna RM Gelzer, Flavio H Fenton, Wei Qian, WeiYe Lin, Robert F Gilmour Jr, Niels F Otani Journal of the American Heart Association 7 (17), e007898
Competing mechanisms of stress-assisted diffusivity and stretch-activated currents in cardiac electromechanics
A Loppini, A Gizzi, R Ruiz-Baier, C Cherubini, FH Fenton, S Filippi JFrontiers in physiology 9, 1714

2017

Introduction to Focus Issue: Complex Cardiac Dynamics
Cherry EM, Fenton FH, Krogh-Madsen T, Luther S, Parlitz U. Chaos, 27(9)
Numerical sensitivity analysis of a variational data assimilation procedure for cardiac conductivities
Barone A, Fenton FH, Veneziani A. Chaos, 27(9)
Efficient parameterization of cardiac action potential models using a genetic algorithm
Cairns D, Fenton FH, Cherry EM. Chaos, 27(9)
Synchronization as a mechanism for low-energy anti-fibrillation pacing
Ji Y, Uzelac I, Otani N, Luther S, Gilmour RF, Cherry EM, Fenton FH. Heart Rhythm, 14(8)
Multi-band decomposition analysis: application to cardiac alternans as a function of temperature
Gizzi A, Loppini A, Cherry EM, Cherubini C, Fenton FH, Filippi S. Physiological Measurement, 38(5)
Mechanism for amplitude alternans in electrocardiograms and the initiation of spatiotemporal chaos
Chen D, Gray RA, Uzelac I, Herndon C, Fenton FH. Physical Review Letters, 118(16)
Level-set Method for Robust Analysis of Optical Mapping Recordings of Fibrillation
Gurevich D, Herndon C, Uzelac I, Fenton FH, Grigoriev R. Computing in Cardiology, 44
Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients
Uzelac I, Ji Y, Hornung D, Schroder-Scheteling J, Luther S, Gray R, Cherry EM, Fenton FH. Frontiers in Physiology, 8(819)
Dynamics of a human spiral wave
Welsh A, Greco E, Fenton FH. Physics Today, 70(2)

2016

Computational ECG reconstruction and validation from high-resolution optical mapping
Herndon C, Uzelac I, Farmer JT, Fenton FH. Computing in Cardiology
Electrocardiogram reconstruction from high resolution voltage optical mapping
Uzelac I, Herndon C, Farmer JT, Fenton FH. IEEE Engineering in Medicine and Biology Society
Book review: Patterns in Excitable Media: Genesis, Dynamics, and Control
Fenton FH Physics today, 69 (2), 48
Reconstructing three-dimensional reentrant cardiac electrical wave dynamics using data assimilation
Hoffman NJ, LaVigne NS, Scorse ST, Fenton FH, Cherry EM Chaos, 26 (1), 013107
Sharp Boundary Electrocardiac Simulations
Xue S, Lim H, Glimm J, Fenton FH, Cherry EM, SIAM Journal on Scientific Computing, 38 (1), B100-B117
Numerical solutions of reaction-diffusion equations: Application to neural and cardiac models
Ji YC, Fenton FH, American Journal of Physics, 84 (626)

2015

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome
Bueno-Orovio A, Cherry EM, Evans SJ, Fenton FH BioMed Research International, 197586, 12 pages
Implementation of Contraction to Electrophysiological Ventricular Myocyte Models, and Their Quantitative Characterization via Post-Extrasystolic Potentiation
Ji YC, Gray RA, Fenton FH PloS One, 10 (8), e0135699
Model-order reduction of ion channel dynamics using approximate bisimulation
Islam MA, Murthy A, Bartocci E, Cherry EM, Fenton FH, Glimm J, Smolka SA, Grosu R. Theoretical Computer Science, 599, 34-46
Robust Framework for Quantitative Analysis of Optical Mapping Signal without Filtering
Uzelac I, Fenton FH. Computers in Cardiology, 461-464

2014

Mechanistic insights into hypothermic ventricular fibrillation: the role of temperature and tissue size
Filippi S, Gizzi A, Cherubini C, Luther S, Fenton FH Europace, 16 (3), 424-434,
Spatio-temporal correlation of paced cardiac tissue
Filippi S, Cherubini C, Gizzi A, Loppini A, Fenton FH . Cardiovascular Oscillations (ESGCO), IEEE, 223-224
Continuous-time control of alternans in long Purkinje fibers
Garzon A, Grigoriev RO, Fenton FH , Chaos, 24 (3), 033124
Modelling the take-off voltage of the action potential during fast pacing
Chen DD, Gray RA, Fenton FH , Computing in Cardiology Conference (CinC), 685-688
Compositional, approximate, and quantitative reasoning for medical cyber-physical systems with application to patient-specific cardiac dynamics and devices
Grosu R, Cherry EM, Clarke EM, Cleaveland R, Dixit S, Fenton FH, Gao S, Glimm J, Gray RA, Mangharam R, Ray A, Smolka SA Leveraging Applications of Formal Methods, Verification and Validation. Specialized Techniques and Applications, 356-364

2013

Validation of a computational model of cardiac defibrillation
Bragard J, Elorza J, Cherry EM, Fenton FH Computing in Cardiology (CinC), 851-854,
High-power current source with real-time arbitrary waveforms for in vivo and in vitro studies of defibrillation
Uzelac I, Holcomb M, Reiserer RS, Fenton FH, Wikswo JP Computing in Cardiology (CinC), 667-670
Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts
Kelly A, Ghouri IA, Kemi OJ, Bishop MJ, Bernus O, Fenton FH, Myles RC, Circulation: Arrhythmia and Electrophysiology, 6 (4), 809-817
Role of temperature on nonlinear cardiac dynamics
FH Fenton, A Gizzi, C Cherubini, N Pomella, S Filippi , Physical Review E, 87 (4), 042717
Curvature analysis of cardiac excitation wavefronts
Murthy A, Bartocci E, Fenton FH, Glimm J, Gray R, Cherry RM, Smolka S, Computational Biology and Bioinformatics, IEEE/ACM Transactions
Study of Cardiac Defibrillation Through Numerical Simulations
Bragard J, Marin S, Cherry EM, Fenton FH Without Bounds: A Scientific Canvas of Nonlinearity and Complex Dynamics
Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue
Gizzi A, Cherry EM, GilmourJr RF, Luther S, Filippi S, Fenton FH Frontiers in physiology, 4

2012

Contribution of the Purkinje network to wave propagation in the canine ventricle: insights from a combined electrophysiological-anatomical model.
Cherry EM, Fenton FH. Nonlinear Dynamics, 68 (3), 365-379
Mechanisms of ventricular arrhythmias: a dynamical systems-based perspective
Cherry EM, Fenton FH, Gilmour RF American Journal of Physiology-Heart and Circulatory Physiology
Low-energy anti-fibrillation pacing (LEAP): A gentle, non traumatic defibrillation option
European Heart Journal, 33, 381-3812012
Approximate bisimulations for sodium channel dynamics
Murthy A, Islam M, Bartocci E, Cherry EM, Fenton RH, Glimm J, Computational Methods in Systems Biology, 267-287

2011

Low-energy control of electrical turbulence in the heart
Luther S*, Fenton FH*, Kornreich BG, Squires A, Bittihn P, Hornung D, Zabel M, Flanders J, Gladuli A, Campoy L, Cherry EM, Luther G, Hasenfuss G, Krinsky VI, Pumir A, Gilmour RF Jr, Bodenschatz E. Nature, Jul 13; 475(7355):235-9(*) Equal first authors.
Effects of boundaries and geometry on the spatial distribution of action potential duration in cardiac tissue
Cherry EM, Fenton FH. Journal of Theoretical Biology, Vol 285, 164-176
Toward Real-time Simulation of Cardiac Dynamics
Bartocci E, Cherry EM, Glimm J, Grosu R, Smolka SA, Fenton FH. , CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 103-110
Curvature Analysis of Cardiac Excitation Wavefronts
Murthy A, Bartocci E, Fenton FH, Glimm J, Gray RA, Smolka SA, and Grosu R. , CMSB 2011 9th International Conference on Computational Methods in Systems Biology, Sept. 21-23 pages 151-160
From Cardiac Cells to Genetic Regulatory Networks
Grosu R, Batt G, Fenton FH, Glimm J, Le Guernic C, Smolka SA, Bartocci E. International Conference on Computer Aided Verification, 6806, pp. 396-411
Verification of cardiac tissue electrophysiology simulations using an N-version benchmark
Niederer SA, Kerfoot E, Benson A, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodriguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O, Smith NP. Transactions of the Royal Society A
Models of cardiac tissue electrophysiology: Progress, challenges and open questions
Clayton RH, Bernus O; Cherry EM; Dierckx H; Fenton FH, Mirabella L, Panfilov S V, Sachse FB, Seeman G; Zhang H. Prog Biophys Mol Biol, 104; 22-48
Cardiac cell modeling: Observations from the heart of the cardiac physiome project
Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, Seemann G, Thul R, Zhang H, Sachse FB, Beard D, Crampin EJ, Smith NP. , Prog Biophys Mol Biol, 104; 2-21
From cardiac cells to genetic regulatory networks
Grosu R, Batt G, Fenton FH, Glimm J, Guernic C Le, Smolka SA, Bartocci E. Computer Aided Verification, 396-411
A Change of Perspective Yields Formal Analysis
Grosu R, Fenton FH, Smolka S, Bartocci E. Software Engineering Workshop (SEW), 34th IEEE, 69-76
Model-based control of cardiac alternans in Purkinje fibers
Garzon A, Grigoriev RO, FH Fenton FH Physical Review E 84 (4), 041927
Teaching cardiac electrophysiology modeling to undergraduate students: laboratory exercises and GPU programming for the study of arrhythmias and spiral wave dynamics
Bartocci E, Singh R, von Stein FB, Fenton FH. Advances in physiology education, 35 (4), 427-437
The Value of Simulation
Fenton FH. Physics World, 23:46-47

2010

Realistic cardiac electrophysiology modeling: are we just a heartbeat away?
Cherry EM and Fenton FH. J. Physiol. 588, 2689

2009

Termination of atrial fibrillation using pulsed low-energy far field stimulation
Fenton FH, Luther S, Otani NF, Cherry EM, Pumir A, Bodenschatz E, Krinsky V, Gilmour RF Jr. Circulation, 120, 467-476
Use of Ultrasound Imaging to Map Propagating Action Potential Waves in the Heart
Otani NF, Singh R, Fenton FH, Butcher J, DW Infanger DW, Neumann A, Luther S, Gilmour Jr RF. Computers in Cardiology
Model-based control of cardiac alternans on a ring
Garzon A, Roman OG, Fenton FH. Physical Review E, 80:021932

2008

Visualization of spiral and scroll waves in simulated and experimental cardiac tissue
Cherry EM, Fenton FH. New J. Phys, 10 125016(Selected as New Journal of Physics Best of 2008 by the editors)
Models of cardiac cell
Fenton FH., Cherry EM. Scholarpedia, 3(8):1868
Termination of equine atrial fibrillation by quinidine: An optical mapping study
Fenton FH, Cherry EM, Kornreich BG. Journal of Veterinary Cardiology, 10 87-102 (Article featured in the Journal Cover)
Predator-prey approach to analyzing complex dynamics in cardiac tissue
Otani NF, Mo A, Mannava S, Fenton FH, Cherry EM, Luther S, Gilmour RF, Jr. Physical Review E, 78, 021913
Cardiac arrhythmia
Fenton FH, Cherry EM, Glass Leon. Scholarpedia; 3(7):1665
Minimal Model for Human Ventricular Action Potential in Tissue
Bueno-Orovio A., Cherry EM, Fenton FH. Journal of Theoretical Biology; 253: 544-560

2007

Pulmonary Vein Reentry-Properties and Size Matter: Insights from a Computational Analysis
Cherry EM., Ehrlich JR, Nattel S, Fenton FH. Heart Rhythm 2007; 12: 1553-1562 (Article featured in the Journal Cover)
A tale of two dogs: analyzing two models of canine ventricular electrophysiology
Cherry EM, Fenton FH. American Journal of Physiology 2007; 292: H43-H55

2006

Spectral Methods for Partial Differential Equations in Irregular Domains: The Spectral Smoothed Boundary Method
Bueno-Orovio A., Perez-Garcia VM., and Fenton FH. SIAM Journal on Scientific Computing 2006; Vol. 28, N.3; 886-900
Reentrant arrhythmias in human ventricular models
Fenton FH, Orovio AB, Evans SJ, Cherry EM Heart Rhythm 2006 3 (5) S186
Tissue dynamics of two models of canine ventricular cell electrophysiology: Restitution, memory and reentry properties
Cherry EM, Gilmour RF, Fenton FH Heart Rhythm 2006 3 (5) S227
Web-based programs for learning cardiac electrophysiology: Interaactive simulations of heart cells and tissue
Fenton FH, Cherry EM, Hastings, HM, Evans SJ Heart Rhythm 2006 3 (5) S136

2005

Modeling Wave Propagation in Realistic Heart Geometries Using the Phase-Field Method
Fenton FH., Cherry EM., Karma A., Rappel WJ. Chaos 2005; 15: 013502
Head-tail interactions in numerical simulations of reentry in a ring of cardiac tissue
Chen X, Fenton FH, Gray RA Heart Rhythm 2005 ; 2 (9), 1038-1046
Fibrillation without alternans in porcine ventricles
Fenton FH, Cherry EM, Gray RA, Hastings HM, Evans SJ. Heart Rhythm 2005 2 (5) S301-S302

2004

Suppression of Alternans and Conduction Blocks Despite Steep APD Restitution: Electrotonic, Memory and Conduction Velocity Restitution Effects
Cherry EM, Fenton FH. American Journal of Physiology 2004; 286: H2332-2341
A simulation study of atrial fibrillation initiation: Differences in resting membrane potential can produce spontaneous activations at the pulmonary vein-left atrial junction
Fenton FH, Cherry EM, Ehrlich JR, Nattel S, Evans SJ. Heart Rhythm 2004 1 S187-S188

2003

Effects of wall heterogeneity in an anatomically realistic model of canine ventricles: A simulation study
Cherry EM, Rappel WJ, Evans SJ, Fenton F PACE 2003 26, 1109

2002

Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity
Fenton FH, Cherry EM, Hastings HM, Evans SJ. Chaos 2002; 12: 852-892
Real-time Computer Simulations of Excitable Media: Java as a Scientific Language and as a Wrapper for C and Fortran Programs
Fenton FH, Cherry EM, Hastings HM, Evans SJ. BioSystems 2002; 64: 73-96

2001

Mechanisms for Discordant Alternans
Watanabe M, Fenton F, Evans S, Hastings H, Karma A. Journal of Cardiovascular Electrophysiology 2001; 12: 196-206

2000

Alternans and the Onset to Ventricular Fibrillation
Hastings H, Fenton F, Evans SJE, Hotomaroglu O, Geetha J, Gittelson K, Nilson J, Garfinkel A. Physical Review E 2000; 62: 4043-4048
Transition from ventricular tachycardia to ventricular fibrillation as a function of tissue characteristics in a computer model
Fenton F, Karma A, Hastings H, Evans SJE. Europace 1 2000
Numerical Simulations of Cardiac Dynamics. What can we learn from simple and complex models?
Fenton F. H. Computers in Cardiology 2000; 251-254

1999

Memory in an excitable medium; A mechanism for spiral wave breakup in the low-excitability limit
Fenton F, Evans S, Hastings H. Physical Review Letters 1999; 83: 3964-3967
Spatiotemporal Control of Wave Instabilities in Cardiac Tissue
Rappel WJ, Fenton F, Karma A. Physical Review Letters 1999; 83: 456-459

1998

Instability of Electrical Vortex Filament and Wave Turbulence in Thick Cardiac Muscle
Fenton F, Karma A. Physical Review Letters 1998; 81: 481-484
Vortex Dynamics in 3D Continuous Myocardium With Fiber Rotation: Filament Instability and Fibrillation
Fenton F, Karma A. Chaos 1998; 8: 20-47. (Errata for table: Chaos 1998; 8: 879.)

1997

A new three-variable mathematical model of action potential propagation in cardiac tissue
Fenton F, Karma A. APS March Meeting Abstract Vol 1. pg. 2012