Complex Heart Arrhythmias and other Oscillating Systems
In the CHAOS Lab, we combine theory, simulation, and experimentation to understand complex cardiometrics.
Mathematical modeling of complex systems
Development and analysis of mathematical models that describe generic or detailed dynamics of excitable and oscillatory media such as in the heart, neurons, chemical reactions, calcium signaling, physical and biological oscillators, etc.
Study of bifurcations and chaotic (organized and disorganized) dynamics of excitable and oscillatory systems.
Develop and apply control methods for suppressing or synchronizing complex dynamics
Study of stability and instabilities of spiral waves and three-dimensional scroll waves in idealized and realistic domains of excitable media
High performance computing
Development and implementation of novel algorithms to solve partial differential equations in two- and three-dimensional regular and irregular domains
Computer modeling of complex systems using supercomputers, as well as graphics cards (GPUs)
Simulations and large data visualization of complex systems in or near real time or over the web
Experiments in complex systems
Studying voltage and calcium dynamics of cardiac tissue using heart sections or whole hearts from fish and mice to large mammals such as horses. Using voltage and calcium senstive dyes and ultrafast cameras, we record the dynamics of voltage and calcium waves and study the instabilities associated with arrhythmias.
Dynamics of spiral and scroll waves
Mechanisms of bifurcation and period-doublings in time and in space
Methods for chaos control and synchronization
Chemical, physical, and other biophysical oscillators with complex dynamics and instabilities such as the saline oscillator and spiral/scroll waves in the Belousov Zhaboutinsky reaction